akari立克次體 IgG ELISA試劑盒

R. akari IgG ELISA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測人血清中的akari立克次體IgG抗體

產(chǎn)品規(guī)格：96T/盒

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akari立克次體 IgG ELISA試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
【企業(yè)文化】

利用酵母和人類細(xì)胞，Smerdon，Mao和他們的研究團(tuán)隊發(fā)現(xiàn)，正常的TCR修復(fù)過程有兩個關(guān)鍵的步驟，以及一種叫做H2B的染色質(zhì)蛋白質(zhì)在*步中起著至關(guān)重要的作用。
為了幫助修復(fù)酶能夠進(jìn)入被大力保護(hù)的DNA中，H2B首先會解開一個較小的蛋白質(zhì)的扣子，就像你在一頓豐富的大餐后放松你的皮帶一樣，這使得DNA鏈放松和分開。隨著鏈的打開，維修人員才有空間進(jìn)來和清楚損傷區(qū)域。
這較小的蛋白質(zhì)的解開，被稱為deubiquitylation。Smerdon和Mao說，這個過程使得DNA的修復(fù)效率更高，并且沒有它的修復(fù)是不可能的。
他們的發(fā)現(xiàn)作為進(jìn)一步研究染色質(zhì)中的DNA修復(fù)在很大程度上的未知領(lǐng)域的基礎(chǔ)。他們的目標(biāo)是更好地了解這一過程在人類身上的工作機(jī)理。
基因療法
“即使在基本技術(shù)層面上，我也沒有忽視這項研究zui終對人體健康而言所能做的，” Smerdon說。
“其中一個正在開發(fā)的治療方法是靶向基因療法，”他說。“如果一個病人有一個特定的基因突變，這個療法會為他們提供一個正常的拷貝來試圖糾正變異基因。雖然它已在某些疾病已經(jīng)成功地做到這一點(diǎn)，但它仍然被修復(fù)缺陷案例中研究。”
Mao推測，在未來，有DNA修復(fù)問題的人可能會吃一種可以提供修復(fù)酶活性的藥物，就可以達(dá)到治療的目的。但這個想法還沒有任何臨床試驗。
周圍神經(jīng)損傷后的自身功能恢復(fù)往往有限，因此，生物工程神經(jīng)移植物復(fù)合細(xì)胞外基質(zhì)分子，生長因子,藥物學(xué)輔助，及細(xì)胞移植修復(fù)周圍神經(jīng)損傷等都成為研究熱點(diǎn)。脂肪干細(xì)胞已被證實具有成脂肪，成骨，成軟骨 多種分化潛能，因其材料來源廣泛，取材容易，分化為神經(jīng)元能力強(qiáng)，倫理學(xué)爭議少等優(yōu)點(diǎn)，使其成為神經(jīng)導(dǎo)管上覆蓋的優(yōu)秀種子細(xì)胞。
英國曼徹斯特大學(xué)炎癥與修復(fù)研究所Blond McIndoe 實驗室主要研究GABA及其他神經(jīng)遞質(zhì)周圍神經(jīng)系統(tǒng)及成體干細(xì)胞中的作用，他們發(fā)現(xiàn)，特異性抑制P2X7受體能夠拯救ATP誘發(fā)細(xì)胞死亡，這可能解決神經(jīng)損傷處干細(xì)胞移植成活率低的問題。作者的研究可能為神經(jīng)修復(fù)結(jié)合細(xì)胞療法和藥物干預(yù)的發(fā)展指出新的方向。相關(guān)研究觀點(diǎn)發(fā)表在《中國神經(jīng)再生研究(英文版)》雜志2014年7月第14 期雜志上。

Using yeast and human cells, Smerdon, Mao and their team found two key steps in the normal TCR repair process, as well as a chromatin protein called H2B that plays a crucial role in the first step.
To help the repair enzyme get into well-protected DNA, H2B will first unbutton a smaller protein just as you relax your belt after a rich meal, which relaxes and separates the DNA strand . As the chain opens, maintenance personnel have room to come in and clear the damaged area.
The solution of this smaller protein is called deubiquitylation. Smerdon and Mao said that this process makes the DNA repair more efficient, and without its repair is impossible.
Their findings serve as a basis for furthering the largely unknown area of ??DNA repair in chromatin. Their goal is to better understand the working mechanism of this process on human beings.
Gene therapy
"Even at the basic technical level, I did not neglect what the research could ultimay do to human health," Smerdon said.
"One of the treatments that is being developed is targeted gene therapy," he said. "If a patient has a particular mutation, the therapy will provide them with a normal copy in an attempt to correct the variant gene.Although it has been successfully done in certain diseases, it is still being fixed in the case of defects the study."
Mao speculated that in the future, people with DNA repair problems may eat a drug that provides repair enzyme activity for therapeutic purposes. But this idea has not had any clinical trial yet.
Peripheral nerve injury after their own functional recovery is often limited, therefore, bioengineered nerve graft compound extracellular matrix molecules, growth factors, pharmacological assistance, and cell transplantation to repair peripheral nerve injury have become the research hotspot. Adipose-derived stem cells have been proven to have multiple adipogenic, osteogenic, and cartilage potential for differentiation because of their wide range of materials, ease of harvesting, strong ability to differentiate into neurons, and less ethical controversy that make them neurotransduction-covered Excellent seed cells.
The Blond McIndoe Laboratory at the Institute of Inflammation and Rehabilitation, University of Manchester, UK, has been investigating the role of GABA and other neurotransmitter peripheral and adult stem cells. They found that specifically inhibiting P2X7 receptors can rescue ATP-induced cell death, which may account for nerve Damage stem cell transplantation survival rate is low. The authors study may point out a new direction for the development of neurorestoratin combined with cell therapy and drug intervention. Relevant research point of view published in the "Chinese Journal of Nerve Regeneration Research (English version)" magazine in July 2014 No. 14 magazine.